02774nab a2200289 i 4500 publ11368 20200221115454.0 170523s2014 hu o 0|| zxx d 0031-9384 10.1016/j.physbeh.2013.11.007 doi 2497687 mtmt SZTE Publicatio Repozitórium hun zxx Petrovszki Zita The effects of juvenile capsaicin desensitization in rats [elektronikus dokumentum] : Behavioral impairments / Petrovszki Zita Elsevier Science 2014 38-44 PHYSIOLOGY & BEHAVIOR 125 Capsaicin desensitization leads to behavioral changes, some of which are related to schizophrenia, but investigations into these effects have been scarce. The goal of this study was to characterize the consequences of juvenile capsaicin desensitization on different functions: acute and inflammation-induced thermal and mechanical sensitivity, urinary bladder capacity and thermoregulation, and also on the potentially schizophrenia-related impairments in sensory-motor gating, motor activity and cognitive functioning. Male Wistar rats desensitized with increasing doses of subcutaneous capsaicin after weaning were investigated. Heat and mechanical pain sensitivity did not change significantly; however, morphine produced a prolonged decrease in the nociceptive response to inflammation in desensitized animals. Ultrasound examination of the bladder revealed enhanced bladder volume in treated animals. Capsaicin-treated animals had higher body temperature at 22 degrees C in both dark and light periods, and they also showed prolonged hyperthermia in new environmental circumstances. Warm environment induced a profound impairment of thermoregulation in desensitized animals. The treated animals also showed higher levels of activity during the active phase and at both cool and warm temperatures. The amplitude of the responses to auditory stimuli and prepulse inhibition did not differ between the two groups, but the desensitized animals showed learning impairments in the novel object recognition test. These results suggest that juvenile capsaicin desensitization leads to sustained changes in several functions that may be related to schizophrenia. We propose that capsaicin desensitization, together with other interventions, may lead to an improved chronic animal model of schizophrenia. Adám Gábor aut Kékesi Gabriella aut Tuboly Gábor aut Morvay Zita aut Nagy Endre aut Benedek György aut Horváth Gyöngyi aut http://publicatio.bibl.u-szeged.hu/11368/1/Petrovszki_PhysiolBehav_2014.pdf Dokumentum-elérés