Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease
Huntington's Disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2018
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| Sorozat: | HUMAN MOLECULAR GENETICS
27 No. 4 |
| doi: | 10.1093/hmg/ddx432 |
| mtmt: | 3308300 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12897 |