Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex
Diverse neocortical GABAergic neurons specialize in synaptic targeting and their effects are modulated by presynaptic metabotropic glutamate receptors (mGluRs) suppressing neurotransmitter release in rodents, but their effects in human neocortex are unknown. We tested whether activation of group III...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | CEREBRAL CORTEX
33 No. 5 |
| Tárgyszavak: | |
| doi: | 10.1093/cercor/bhac195 |
| mtmt: | 32921240 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/26630 |
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| 024 | 7 | |a 10.1093/cercor/bhac195 |2 doi | |
| 024 | 7 | |a 32921240 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Lukács István P. | |
| 245 | 1 | 0 | |a Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex |h [elektronikus dokumentum] / |c Lukács István P. |
| 260 | |c 2023 | ||
| 300 | |a 2101-2142 | ||
| 490 | 0 | |a CEREBRAL CORTEX |v 33 No. 5 | |
| 520 | 3 | |a Diverse neocortical GABAergic neurons specialize in synaptic targeting and their effects are modulated by presynaptic metabotropic glutamate receptors (mGluRs) suppressing neurotransmitter release in rodents, but their effects in human neocortex are unknown. We tested whether activation of group III mGluRs by L-AP4 changes GABA(A) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in 2 distinct dendritic spine-innervating GABAergic interneurons recorded in vitro in human neocortex. Calbindin-positive double bouquet cells (DBCs) had columnar "horsetail" axons descending through layers II-V innervating dendritic spines (48%) and shafts, but not somata of pyramidal and nonpyramidal neurons. Parvalbumin-expressing dendrite-targeting cell (PV-DTC) axons extended in all directions innervating dendritic spines (22%), shafts (65%), and somata (13%). As measured, 20% of GABAergic neuropil synapses innervate spines, hence DBCs, but not PV-DTCs, preferentially select spine targets. Group III mGluR activation paradoxically increased the frequency of sIPSCs in DBCs (to median 137% of baseline) but suppressed it in PV-DTCs (median 92%), leaving the amplitude unchanged. The facilitation of sIPSCs in DBCs may result from their unique GABAergic input being disinhibited via network effect. We conclude that dendritic spines receive specialized, diverse GABAergic inputs, and group III mGluRs differentially regulate GABAergic synaptic transmission to distinct GABAergic cell types in human cortex. | |
| 650 | 4 | |a Biológiai tudományok | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Francavilla Ruggiero |e aut |
| 700 | 0 | 1 | |a Field Martin |e aut |
| 700 | 0 | 1 | |a Hunter Emily |e aut |
| 700 | 0 | 1 | |a Howarth Michael |e aut |
| 700 | 0 | 1 | |a Horie Sawa |e aut |
| 700 | 0 | 1 | |a Plaha Puneet |e aut |
| 700 | 0 | 1 | |a Stacey Richard |e aut |
| 700 | 0 | 1 | |a Livermore Laurent |e aut |
| 700 | 0 | 1 | |a Ansorge Olaf |e aut |
| 700 | 0 | 1 | |a Tamás Gábor |e aut |
| 700 | 0 | 1 | |a Somogyi Péter |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/26630/7/32921240_megjelent.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/26630/1/Differentialeffects...bhac195.pdf |z Dokumentum-elérés |