Protein interactions on telomeric retrotransposons in Drosophila
Telomere length in Drosophila is maintained by targeted transposition of three non-LTR retrotransposons: HeT-A, TART and TAHRE (HTT), but understanding the regulation of this process is hindered by our poor knowledge of HTT associated proteins. We have identified new protein components of the HTT ar...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2012
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| Sorozat: | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
8 No. 7 |
| Tárgyszavak: | |
| doi: | 10.7150/ijbs.4460 |
| mtmt: | 2170038 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/34307 |
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| 008 | 240725s2012 hu o 000 eng d | ||
| 022 | |a 1449-2288 | ||
| 024 | 7 | |a 10.7150/ijbs.4460 |2 doi | |
| 024 | 7 | |a 2170038 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Takács Sándor | |
| 245 | 1 | 0 | |a Protein interactions on telomeric retrotransposons in Drosophila |h [elektronikus dokumentum] / |c Takács Sándor |
| 260 | |c 2012 | ||
| 300 | |a 1055-1061 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES |v 8 No. 7 | |
| 520 | 3 | |a Telomere length in Drosophila is maintained by targeted transposition of three non-LTR retrotransposons: HeT-A, TART and TAHRE (HTT), but understanding the regulation of this process is hindered by our poor knowledge of HTT associated proteins. We have identified new protein components of the HTT array: Chromator (Chro), the TRF2/DREF complex and the sumoylation machinery. Chro was localized on telomeric HTT arrays by immunostaining, where it may interact with Prod directly, as indicated by yeast two-hybrid interaction, co-IP, and colocalization on polytene chromosomes. The TRF2/DREF complex may promote the open structure of HTT chromatin. The protein interactions controlling HTT chromatin structure and telomere length may be modulated by sumoylation. | |
| 650 | 4 | |a Biológiai tudományok | |
| 700 | 0 | 1 | |a Biessmann Harald |e aut |
| 700 | 0 | 1 | |a Reddy Hemakumar M. |e aut |
| 700 | 0 | 1 | |a Mason James M. |e aut |
| 700 | 0 | 1 | |a Török Tibor |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/34307/1/takacs_et_al_2012.pdf |z Dokumentum-elérés |