Synthesis and Transformation of Tricyclic KYNA Derivatives
Kynurenic acid (KYNA) derivatives condensed with an aromatic ring (tricyclic KYNA derivatives) have been successfully synthesized, and the reactivity of these analogues has been investigated in the modified Mannich reaction resulting in new Mannich bases. The N,N-dimethyl-ethylenediamine analogues o...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2025
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
26 No. 13 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms26136248 |
| mtmt: | 36228601 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/37183 |
| LEADER | 01561nab a2200253 i 4500 | ||
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| 005 | 20250708125432.0 | ||
| 008 | 250708s2025 hu o 000 eng d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms26136248 |2 doi | |
| 024 | 7 | |a 36228601 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sárik Julián Robin | |
| 245 | 1 | 0 | |a Synthesis and Transformation of Tricyclic KYNA Derivatives |h [elektronikus dokumentum] / |c Sárik Julián Robin |
| 260 | |c 2025 | ||
| 300 | |a 15 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 26 No. 13 | |
| 520 | 3 | |a Kynurenic acid (KYNA) derivatives condensed with an aromatic ring (tricyclic KYNA derivatives) have been successfully synthesized, and the reactivity of these analogues has been investigated in the modified Mannich reaction resulting in new Mannich bases. The N,N-dimethyl-ethylenediamine analogues of the tricyclic KYNA derivatives have also been successfully synthesized, and their reactivity in the modified Mannich reaction was investigated. The synthesized ring systems bear resemblance to molecules previously investigated as G-quadruplex binding agents. Based on this similarity, the synthesized tricyclic KYNA derivatives could be investigated as potential antiviral and anticancer molecules. | |
| 650 | 4 | |a Kémiai tudományok | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Szatmári István |e aut |
| 700 | 0 | 1 | |a Lőrinczi Bálint |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/37183/1/IntJMolSci_6248_Sarik_2025.pdf |z Dokumentum-elérés |