Syntheses and Antiproliferative Effects of D-homo- and D-secoestrones
Abstract Substituted and/or heterocyclic D-homoestrone derivatives were synthetized via the intramolecular cyclization of a δ-alkenyl-D-secoaldehyde, -D-secoalcohol or -D-secocarboxylic acid of estrone 3-benzyl ether. The D-secoalcohol was modified at three sites in the molecule. The in vitro antipr...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2014
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| Sorozat: | STEROIDS
87 No. 0 |
| doi: | 10.1016/j.steroids.2014.05.015 |
| mtmt: | 2602154 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8318 |
| LEADER | 01954nab a2200337 i 4500 | ||
|---|---|---|---|
| 001 | publ8318 | ||
| 005 | 20190517123326.0 | ||
| 008 | 170329s2014 hu o 0|| angol d | ||
| 022 | |a 0039-128X | ||
| 024 | 7 | |a 10.1016/j.steroids.2014.05.015 |2 doi | |
| 024 | 7 | |a 2602154 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Mernyák Erzsébet | |
| 245 | 1 | 0 | |a Syntheses and Antiproliferative Effects of D-homo- and D-secoestrones |h [elektronikus dokumentum] / |c Mernyák Erzsébet |
| 260 | |c 2014 | ||
| 300 | |a 128-136 | ||
| 490 | 0 | |a STEROIDS |v 87 No. 0 | |
| 520 | 3 | |a Abstract Substituted and/or heterocyclic D-homoestrone derivatives were synthetized via the intramolecular cyclization of a δ-alkenyl-D-secoaldehyde, -D-secoalcohol or -D-secocarboxylic acid of estrone 3-benzyl ether. The D-secoalcohol was modified at three sites in the molecule. The in vitro antiproliferative activities of the new D-homo- and D-secoestrone derivatives were determined on HeLa, MCF-7, A431 and A2780 cells through use of MTT assay. D-Homoalcohols 3 and 5 displayed cell line-selective cytostatic effects against ovarian and cervical cell lines, respectively. Two D-secoestrones (6 and 12c) proved to be effective, with IC50 values comparable with those of the reference agent cisplatin. A selected compound (6) was tested by tubulin polymerization assay and its cancer specificity was additionally determined by using noncancerous human fibroblast cells. | |
| 700 | 0 | 1 | |a Szabó Johanna |e aut |
| 700 | 0 | 1 | |a Bacsa Ildikó |e aut |
| 700 | 0 | 1 | |a Huber Judit |e aut |
| 700 | 0 | 1 | |a Schneider Gyula |e aut |
| 700 | 0 | 1 | |a Minorics Renáta |e aut |
| 700 | 0 | 1 | |a Bózsity Noémi |e aut |
| 700 | 0 | 1 | |a Zupkó István |e aut |
| 700 | 0 | 1 | |a Varga Mónika |e aut |
| 700 | 0 | 1 | |a Bikádi Zsolt |e aut |
| 700 | 0 | 1 | |a Hazai Eszter |e aut |
| 700 | 0 | 1 | |a Wölfling János |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8318/1/Steroids_dhomo_seco_u.pdf |z Dokumentum-elérés |