Development of and Recovery from Secondary Hypogonadism in Aging Men Prospective Results from the EMAS /
CONTEXT: Secondary hypogonadism is common in aging men; its natural history and predisposing factors are unclear. OBJECTIVES: The objectives were 1) to identify factors that predispose eugonadal men (T >/= 10.5 nmol/L) to develop biochemical secondary hypogonadism (T < 10.5 nmol/L; LH </=...
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| Dokumentumtípus: | Cikk |
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Endocrine Society Press
2015
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| Sorozat: | JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
100 No. 8 |
| doi: | 10.1210/jc.2015-1571 |
| mtmt: | 3012126 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8367 |
| LEADER | 03808nab a2200373 i 4500 | ||
|---|---|---|---|
| 001 | publ8367 | ||
| 005 | 20190515124013.0 | ||
| 008 | 160706s2015 hu o 0|| angol d | ||
| 022 | |a 0021-972X | ||
| 024 | 7 | |a 10.1210/jc.2015-1571 |2 doi | |
| 024 | 7 | |a 3012126 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Rastrelli Giulia | |
| 245 | 1 | 0 | |a Development of and Recovery from Secondary Hypogonadism in Aging Men |h [elektronikus dokumentum] : |b Prospective Results from the EMAS / |c Rastrelli Giulia |
| 260 | |a Endocrine Society Press |c 2015 | ||
| 300 | |a 3172-3182 | ||
| 490 | 0 | |a JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM |v 100 No. 8 | |
| 520 | 3 | |a CONTEXT: Secondary hypogonadism is common in aging men; its natural history and predisposing factors are unclear. OBJECTIVES: The objectives were 1) to identify factors that predispose eugonadal men (T >/= 10.5 nmol/L) to develop biochemical secondary hypogonadism (T < 10.5 nmol/L; LH </= 9.4 U/L) and secondary hypogonadal men to recover to eugonadism; and 2) to characterize clinical features associated with these transitions. DESIGN: The study was designed as a prospective observational general population cohort survey. SETTING: The setting was clinical research centers. PARTICIPANTS: The participants were 3369 community-dwelling men aged 40-79 years in eight European centers. INTERVENTION: Interventions included observational follow-up of 4.3 years. MAIN OUTCOME MEASURE: Subjects were categorized according to change/no change in biochemical gonadal status during follow-up as follows: persistent eugonadal (n = 1909), incident secondary hypogonadal (n = 140), persistent secondary hypogonadal (n = 123), and recovered from secondary hypogonadism to eugonadism (n = 96). Baseline predictors and changes in clinical features associated with incident secondary hypogonadism and recovery from secondary hypogonadism were analyzed by regression models. RESULTS: The incidence of secondary hypogonadism was 155.9/10 000/year, whereas 42.9% of men with secondary hypogonadism recovered to eugonadism. Incident secondary hypogonadism was predicted by obesity (body mass index >/= 30 kg/m(2); odds ratio [OR] = 2.86 [95% confidence interval, 1.67; 4.90]; P < .0001), weight gain (OR = 1.79 [1.15; 2.80]; P = .011), and increased waist circumference (OR = 1.73 [1.07; 2.81], P = .026; and OR = 2.64 [1.66; 4.21], P < .0001, for waist circumference 94-102 and >/=102 cm, respectively). Incident secondary hypogonadal men experienced new/worsening sexual symptoms (low libido, erectile dysfunction, and infrequent spontaneous erections). Recovery from secondary hypogonadism was predicted by nonobesity (OR = 2.28 [1.21; 4.31]; P = .011), weight loss (OR = 2.24 [1.04; 4.85]; P = .042), normal waist circumference (OR = 1.93 [1.01; 3.70]; P = .048), younger age (< 60 y; OR = 2.32 [1.12; 4.82]; P = .024), and higher education (OR = 2.11 [1.05; 4.26]; P = .037), but symptoms did not show significant concurrent improvement. CONCLUSION: Obesity-related metabolic and lifestyle factors predispose older men to the development of secondary hypogonadism, which is frequently reversible with weight loss. | |
| 700 | 0 | 1 | |a Carter Emma L. |e aut |
| 700 | 0 | 1 | |a Ahern Tomas |e aut |
| 700 | 0 | 1 | |a Finn Joseph D. |e aut |
| 700 | 0 | 1 | |a Antonio Leen |e aut |
| 700 | 0 | 1 | |a O’Neill Terence W. |e aut |
| 700 | 0 | 1 | |a Bártfai György |e aut |
| 700 | 0 | 1 | |a Casanueva Felipe F. |e aut |
| 700 | 0 | 1 | |a Forti Gianni |e aut |
| 700 | 0 | 1 | |a Keevil Brian |e aut |
| 700 | 0 | 1 | |a Maggi Mario |e aut |
| 700 | 0 | 1 | |a Giwercman Aleksander |e aut |
| 700 | 0 | 1 | |a Han Thang S. |e aut |
| 700 | 0 | 1 | |a Földesi Imre |e aut |
| 700 | 0 | 1 | |a EMAS Study Group |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8367/1/Rastrelli_2015_JCEM_publisher_u.pdf |z Dokumentum-elérés |