01852nab a2200337 i 4500 publ9950 20200128115320.0 161116s2009 hu o 0|| zxx d 0165-5728 10.1016/j.jneuroim.2009.01.004 doi 1230928 mtmt SZTE Publicatio Repozitórium hun zxx Losonczi Erika Tumour necrosis factor alpha gene (TNF-alpha)-376 polymorphism in Hungarian patients with primary progressive multiple sclerosis [elektronikus dokumentum] / Losonczi Erika 2009 115-118 JOURNAL OF NEUROIMMUNOLOGY 208 No. 1-2 Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p=0.027; p=0.032). The G allele may be one of the factors responsible for progression in PPMS. Bencsik Krisztina aut Fricska-Nagy Zsanett aut Honti Viktor aut Szalczer Estilla aut Rajda Cecília aut Illés Zsolt László aut Mátyás Klotild aut Rózsa Csilla aut Csépány Tünde aut Füvesi Judit aut Vécsei László aut http://publicatio.bibl.u-szeged.hu/9950/1/Losonczi_E._Tumour_necrosis_u.pdf Dokumentum-elérés