Protective effects of black shallot extract against acetaminophen-induced nephrotoxicity in mice
Acetaminophen (APAP), widely recognized for its analgesic and antipyretic properties, poses a risk of renal toxicity in cases of overdose. Traditional herbal remedies are frequently employed to counteract drug-induced renal damage. This study focuses on black shallot, an innovative food product deri...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
University of Szeged
Szeged
2023
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| Sorozat: | Acta biologica Szegediensis
67 No. 2 |
| Kulcsszavak: | Toxikológia, Veseélettan, Patofiziológia, Gyógyszerkémia |
| Tárgyszavak: | |
| doi: | 10.14232/abs.2023.2.177-185 |
| Online Access: | http://acta.bibl.u-szeged.hu/86947 |
| Tartalmi kivonat: | Acetaminophen (APAP), widely recognized for its analgesic and antipyretic properties, poses a risk of renal toxicity in cases of overdose. Traditional herbal remedies are frequently employed to counteract drug-induced renal damage. This study focuses on black shallot, an innovative food product derived from Allium ascalonicum, a plant highly valued in traditional Vietnamese medicine. The aim is to explore the protective effects of black shallot ethanol extract (BSEE) against APAP-induced nephrotoxicity in mice. BSEE was orally administered at various doses (200, 250, and 300 mg/kg) in combination with APAP (3 g/kg). N-acetylcysteine (NAC) (50 mg/kg) served as the reference drug, while saline (10 mL/kg) functioned as the negative control. Evaluations encompassed renal histology, serum and urine renal function tests, antioxidant enzyme concentrations (SOD, CAT, and GPx), lipid peroxidation, and anti-inflammatory cytokines (TNF-α, IL-1β, and IL-6). The findings indicated significant alterations in total protein, albumin, BUN, and serum/urine CRE concentrations (P < 0.05), coupled with a decrease in malondialdehyde (MDA) levels (P < 0.05) and inflammatory cytokines TNF-α, IL-1β, and IL-6 (P < 0.05). Remarkable elevations were observed in antioxidant enzyme concentrations, including renal catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) (P < 0.05). The macroscopic and microscopic structures of the kidneys exhibited significant improvement. Consequently, BSEE effectively safeguards against APAP-induced renal damage, as evidenced by enhanced renal structure, reduced inflammation, and biochemical modulation, highlighting its potential therapeutic application in preventing APAP-induced nephrotoxicity. |
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| Terjedelem/Fizikai jellemzők: | 177-185 |
| ISSN: | 1588-4082 |