Mass spectrometry-based insights into human brain ganglioside dynamics in health and neurological disorders
Gangliosides (GGs), glycosphingolipids abundant in the central nervous system (CNS), regulate neural development and signaling, making them valuable as biomarkers and therapeutic targets. Due to their involvement in neural development and signaling, GGs are valuable indicators for the early diagnosi...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2025
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
31 |
| Kulcsszavak: | Analitikai kémia, Tömegspektrometria, Neurokémia, Biokémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/88612 |
| Tartalmi kivonat: | Gangliosides (GGs), glycosphingolipids abundant in the central nervous system (CNS), regulate neural development and signaling, making them valuable as biomarkers and therapeutic targets. Due to their involvement in neural development and signaling, GGs are valuable indicators for the early diagnosis of CNS pathologies. We report a nanoelectrospray ionization (nanoESI) ion mobility spectrometry (IMS) mass spectrometry (MS) and collisioninduced dissociation (CID) tandem MS platform for high-resolution CNS glycolipidomics. Applied to brain tissues, tumors, and cerebrospinal fluid [1-3], this method revealed tumorassociated alterations in GG composition, including increased glycoform and ceramide diversity, enhanced sialylation, and novel acetate-modified structures. These alterations underscore GG overexpression in glioblastoma and metastases as promising diagnostic markers and therapeutic targets, establishing a powerful workflow for brain tumor and neurodegenerative disease research. |
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| Terjedelem/Fizikai jellemzők: | 34-35 |
| ISBN: | 978-963-688-078-1 |