Enhanced solubilization of ketoprofen using Triton X-100, Triton X-165, Brij C10, and their mixed micelle systems
Ketoprofen, a Biopharmaceutics Classification System (BCS) class II drug, exhibits poor aqueous solubility, which limits its bioavailability and therapeutic performance. To address this, we investigated micellar systems composed of Triton X-100, Triton X-165, and Brij C10, studied individually and i...
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| Dokumentumtípus: | Könyv része |
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University of Szeged
Szeged
2025
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
31 |
| Kulcsszavak: | Gyógyszerkémia, Fizikai kémia, Kolloidkémia, Gyógyszertechnológia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/88621 |
| Tartalmi kivonat: | Ketoprofen, a Biopharmaceutics Classification System (BCS) class II drug, exhibits poor aqueous solubility, which limits its bioavailability and therapeutic performance. To address this, we investigated micellar systems composed of Triton X-100, Triton X-165, and Brij C10, studied individually and in binary and ternary mixtures, with the aim of enhancing solubilization efficiency. Critical micelle concentrations (cmc) were determined by fluorescence spectroscopy using pyrene as a probe, and the thermodynamics of mixed micelle formation were evaluated by Rubingh’s model, Regular Solution Theory, and the Margules function to obtain interaction parameters and excess Gibbs free energies. Solubilization of ketoprofen was quantified by HPLC in terms of molar solubilization ratios and partition coefficients. Brij C10 exhibited the lowest cmc and the highest solubilization capacity, with molar solubilization ratios exceeding 6, while Triton micelles showed lower efficiency. Binary Brij–Triton mixtures revealed synergistic stabilization but occasional antagonistic solubilization, highlighting a trade-off between stability and drug incorporation. The ternary system, although thermodynamically stable, showed reduced solubilization due to compact packing. Overall, Brij-rich systems proved to be the most effective carriers, combining low cmc with high solubilization efficiency. These findings provide a thermodynamic basis for the rational design of surfactant mixtures for the solubilization of poorly water-soluble drugs. |
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| Terjedelem/Fizikai jellemzők: | 61-63 |
| ISBN: | 978-963-688-078-1 |