Unravelling the complexity of human brain glycosaminoglycans a study of chondroitin/dermatan sulfates by ion mobility mass spectrometry /
Glycosaminoglycans (GAGs), particularly chondroitin sulfate (CS) and dermatan sulfate (DS), regulate brain processes through specific sulfation motifs. We report the first application of ion mobility spectrometry (IMS) mass spectrometry (MS) to neural GAG analysis. CS/DS octamers from mouse brain we...
Elmentve itt :
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2025
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
31 |
| Kulcsszavak: | Neurokémia, Tömegspektrometria |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/88690 |
| Tartalmi kivonat: | Glycosaminoglycans (GAGs), particularly chondroitin sulfate (CS) and dermatan sulfate (DS), regulate brain processes through specific sulfation motifs. We report the first application of ion mobility spectrometry (IMS) mass spectrometry (MS) to neural GAG analysis. CS/DS octamers from mouse brain were profiled, revealing separation by sulfation content and glucuronic acid type. Eighteen distinct DS-rich domains were identified, including rare under- and oversulfated motifs. IMS MS/MS further resolved isomers and uncovered unusual trisulfated and pentasulfated structures. This approach advances brain glycosaminoglycomics and highlights novel, potentially bioactive CS/DS domains. |
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| Terjedelem/Fizikai jellemzők: | 267-268 |
| ISBN: | 978-963-688-078-1 |