Periodic Nucleation of Calcium Phosphate in a Stirred Biocatalytic Reaction
Highly ordered superstructures composed of inorganic nanoparticles appear in natural and synthetic systems, however the mechanisms of non-equilibrium self-organization that may be involved are still poorly understood. Herein, we performed a kinetic investigation of the precipitation of calcium phosp...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
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| Sorozat: | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
59 No. 7 |
| doi: | 10.1002/anie.201911213 |
| mtmt: | 31131403 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18594 |
| Tartalmi kivonat: | Highly ordered superstructures composed of inorganic nanoparticles appear in natural and synthetic systems, however the mechanisms of non-equilibrium self-organization that may be involved are still poorly understood. Herein, we performed a kinetic investigation of the precipitation of calcium phosphate using a process widely found in microorganisms: the hydrolysis of urea by enzyme urease. With high initial ratio of calcium ion to phosphate, periodic precipitation was obtained accompanied by pH oscillations in a well-stirred, closed reactor. We propose that an internal pH-regulated change in the concentration of phosphate ion is the driving force for periodicity. A simple model involving the biocatalytic reaction network coupled with burst nucleation of nanoparticles above a critical supersaturation reproduced key features of the experiments. These findings may provide insight to the self-organization of nanoparticles in biomineralization and improve design strategies of biomaterials for medical applications. |
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| Terjedelem/Fizikai jellemzők: | 2823-2828 |
| ISSN: | 1433-7851 |