Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid possible glutamatergic and dopaminergic involvement /
3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats once in 20 mg/kg b.w. dose, and the resulting behavioural alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter syste...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2009
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| Sorozat: | ACTA BIOLOGICA HUNGARICA (1983-2018)
60 No. 4 |
| Tárgyszavak: | |
| doi: | 10.1556/ABiol.60.2009.4.3 |
| mtmt: | 1294317 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/27631 |
| Tartalmi kivonat: | 3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats once in 20 mg/kg b.w. dose, and the resulting behavioural alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioural effect of 3-NP. |
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| Terjedelem/Fizikai jellemzők: | 359-367 |
| ISSN: | 0236-5383 |