Immunotoxic effects of MPT-IP containing 60% methylparathion in mice
The effects of a single large and repeated small doses of MPT-IP (the industrial product used to produce Wofatox EC 50) containing 60% methylparathion, on the humoral and cellular immunoreactivity of CFLP mice were investigated. Administration of a single LD50/2 dose 3 d prior to immunization caused...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | HUMAN & EXPERIMENTAL TOXICOLOGY
11 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1177/096032719201100102 |
| mtmt: | 2139152 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32240 |
| Tartalmi kivonat: | The effects of a single large and repeated small doses of MPT-IP (the industrial product used to produce Wofatox EC 50) containing 60% methylparathion, on the humoral and cellular immunoreactivity of CFLP mice were investigated. Administration of a single LD50/2 dose 3 d prior to immunization caused a 40% increase in the number of splenic PFC on the 5th day but no significant increase in serum antibody titre on the 7th day after immunization. Treatment for 4 weeks with an LD50/40 dose resulted in a 100% increase in splenic PFC, also not associated with a change in serum antibody titre. Under the same conditions and LD50/20 dose had no effect on these parameters. Neither the single large nor the repeated small doses had any effect on the intensity or time course of a DTH reaction. The results show that MPT-IP has an immunotoxic potential in mice under certain experimental conditions. |
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| Terjedelem/Fizikai jellemzők: | 11-16 |
| ISSN: | 0960-3271 |