Inhibition of biological effects of endotoxins by phenothiazines
The importance of change transfer reaction involving endotoxins of bacteria and interactions between endotoxin-induced tumor necrosis factor (TNF) were investigated both in vitro and in vivo in the presence of several phenothiazines. Complex formation between endotoxins and ring-substituted phenothi...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | IN VIVO
6 No. 2 |
| Tárgyszavak: | |
| mtmt: | 1413061 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32258 |
| Tartalmi kivonat: | The importance of change transfer reaction involving endotoxins of bacteria and interactions between endotoxin-induced tumor necrosis factor (TNF) were investigated both in vitro and in vivo in the presence of several phenothiazines. Complex formation between endotoxins and ring-substituted phenothiazines, benzodiazepines, amantadine and promethazine was measured using spectrophotometric methods. The endotoxin-induced hypotensive effect was prevented by phenothiazine pretreatment of the dogs; however, the endotoxin-phenothiazine complex had the same effects as the endotoxin itself. The tumor necrosis factor-inducing ability of endotoxin in human monocytes was prevented by promethazine. The TNF induction by endotoxin was inhibited by promethazine in vivo. |
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| Terjedelem/Fizikai jellemzők: | 205-210 |
| ISSN: | 0258-851X |