Saturated Heterocycles, 216. Synthesis, structure and ring opening of trans-perhydro-1,4-benzoxazepin-3-one derivatives
trans-Perhydro-1,4-benzoxazepin-3-ones 2a-e were synthesized and transformed to condensed-skeleton perhydro-trans-1,4-benzoxazepines 3a,b, the thiones 4a-b, the urea derivatives 5a,b, and N-acylated compounds 6a-e. Compounds 6b,d were ring-opened by hydrochloric acid in ethanol to yield trans-2-(1-c...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1995
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| Sorozat: | JOURNAL OF HETEROCYCLIC CHEMISTRY
32 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1002/jhet.5570320126 |
| mtmt: | 27999 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32480 |
| Tartalmi kivonat: | trans-Perhydro-1,4-benzoxazepin-3-ones 2a-e were synthesized and transformed to condensed-skeleton perhydro-trans-1,4-benzoxazepines 3a,b, the thiones 4a-b, the urea derivatives 5a,b, and N-acylated compounds 6a-e. Compounds 6b,d were ring-opened by hydrochloric acid in ethanol to yield trans-2-(1-carbethoxyethoxy)-1-acylaminomethylcyclohexane derivatives 7b,d. The H-1- and C-13-nmr investigation and X-ray analysis of 5b and 6c,d proved that the expected N-acylated derivatives were formed and that both rings of the trans anellated compounds have a chair conformation. |
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| Terjedelem/Fizikai jellemzők: | 161-167 |
| ISSN: | 0022-152X |