CARDIAC RELEASE OF HISTAMINE AFTER VENTRICULAR-FIBRILLATION AND DEFIBRILLATION DURING INSERTION OF IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS (ICD)
Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1995
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| Sorozat: | INFLAMMATION RESEARCH
44 No. 11 |
| Tárgyszavak: | |
| doi: | 10.1007/BF01837917 |
| mtmt: | 1433483 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32490 |
| Tartalmi kivonat: | Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous implantation of ICD. Concomitant arterial and coronary sinus (CS) blood samples were drawn before induction of VF (duration 20 seconds), immediately after, and 2 and 5 min after DEF (18-24 Joules). Basal 2.5 +/- 6 nmol/l, and did not histamine level in CS was 1.1 +/- 0.2 nmol/l before VF (p < 0.008 compared to arterial), and increased to 2.5 +/- 0.6 nmol/l immediately after (p < 0.045 compared to basal), to 3 +/- 1.1 nmol/l 2 mill after (p < 0.45), and to 2.4 +/- 0.8 nmol/l 5 mill after VF. In the basal state there was an uptake of histamine across the coronary circulation. After VF/DEF the level of histamine increased in corollary venous blood, suggesting cardiac release of histamine. |
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| Terjedelem/Fizikai jellemzők: | 499-503 |
| ISSN: | 1023-3830 |