Probability of early infection extinction depends linearly on the virus clearance rate
We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
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| Sorozat: | ROYAL SOCIETY OPEN SCIENCE
11 No. 10 |
| Tárgyszavak: | |
| doi: | 10.1098/rsos.240903 |
| mtmt: | 35433805 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/35543 |
| Tartalmi kivonat: | We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are generated by a hybrid multiscale framework that applies both continuous and discrete mathematical approaches. The central result of our paper is the observation, analysis and explanation of a linear relationship between the virus clearance rate and the probability of early infection extinction. The derivation behind this simple relationship is given by merging different mathematical toolboxes. |
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| Terjedelem/Fizikai jellemzők: | 12 |
| ISSN: | 2054-5703 |