Immunomorphological Analysis of the CD40-CD154 Interaction in T Follicular Helper Cell Lymphoma Emphasizes the Significance of the CD40-CD154 Axis in the Disease
Peripheral T-cell lymphomas (PTCLs) are malignancies of mature T cells with a poor prognosis. Most PTCL cases express follicular T-helper (TFH) cell antigens and are classified as TFH cell lymphoma (TFHL). Contact-dependent signaling between CD40 and its ligand, CD154, is essential for immune functi...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2026
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| Sorozat: | CELLS
15 No. 9 |
| Tárgyszavak: | |
| doi: | 10.3390/cells15090785 |
| mtmt: | 37204511 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/40153 |
| Tartalmi kivonat: | Peripheral T-cell lymphomas (PTCLs) are malignancies of mature T cells with a poor prognosis. Most PTCL cases express follicular T-helper (TFH) cell antigens and are classified as TFH cell lymphoma (TFHL). Contact-dependent signaling between CD40 and its ligand, CD154, is essential for immune functions. CD154 is expressed by activated T cells, while CD40 is found on B cells, follicular and other dendritic cells, macrophages, and stromal cells. Although the CD40-CD154 crosstalk is a key costimulatory pathway in immune responses, data on its role in PTCLs are limited. To explore the role of the CD40-CD154 axis in TFHLs, we conducted an in-depth immunomorphological study of 111 PTCL cases, including 93 TFHL cases. We found that neoplastic T cells in TFHL are consistently CD154-positive. The CD154 expression increased in histologically advanced cases and correlated with the extent of CD40 positivity. We showed that CD154-positive neoplastic T cells recapitulate the intranodal migration of normal TFH cells, disrupting and remodeling each functional compartment, thereby explaining the disease-related immune dysfunction. Our findings indicate that pathological CD40-CD154 interaction is a potential driver mechanism in TFHL and offers a promising target for future therapies. |
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| Terjedelem/Fizikai jellemzők: | 21 |
| ISSN: | 2073-4409 |